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. 2021 Jan 19;21:82. doi: 10.1186/s12885-021-07806-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — BCOR regulated HOX cluster genes and S100A protein genes. Jurkat cells were transfected with wild-type BCOR or BCOR K607E mutant expressing plasmids, and scrambled siRNA or BCOR siRNA. After 48 h, cells were stimulated with PMA and ionomycin for 6 h for analysis of gene expression. a Hierarchical cluster analysis of HOX and S100A protein expression in wild-type BCOR or BCOR K607E mutant expressing cells revealed the upregulation of several HOX genes and S100A protein genes by BCOR K607E mutant. b and c Quantitative PCR validation of differentially expressed genes selected from the microarray analysis between wild-type BCOR and BCOR K607E mutant expressing cells (b) and fresh-frozen tumor samples (c). GAPDH was used as a control to normalize the levels of these transcripts. Data are shown as the mean ± SEM of five independent experiments performed in triplicates (*P < 0.05, **P < 0.01 compared with cells transfected with wild-type BCOR expressing plasmids and wild-type BCOR tumor samples)