Table 1.
Top 10 up-regulated and down-regulated genes by BCOR K607E mutant
| No | Gene Symbol | Gene Title | fold change | |
|---|---|---|---|---|
| K607E/WT | siRNA/WT | |||
| Top 10 up-regulated genes | ||||
| 1 | ISPD | isoprenoid synthase domain containing | 2.88 | 1.74 |
| 2 | ESRG | embryonic stem cell related (non-protein coding) | 2.62 | 1.83 |
| 3 | HOXB6 | homeobox B6 | 2.50 | 2.01 |
| 4 | LOC101929560 | uncharacterized LOC101929560 | 2.48 | 1.62 |
| 5 | CNKSR3 | CNKSR family member 3 | 2.40 | 1.55 |
| 6 | ATP13A4 | ATPase type 13A4 | 2.31 | 1.73 |
| 7 | MAK | male germ cell-associated kinase | 2.28 | 1.60 |
| 8 | SLC7A8 | solute carrier family 7 (amino acid transporter light chain, L system), member 8 | 2.27 | 1.83 |
| 9 | PTAFR | platelet-activating factor receptor | 2.24 | 1.90 |
| 10 | LOC101927250 | uncharacterized LOC101927250 | 2.23 | 1.83 |
| Top 10 down-regulated genes | ||||
| 1 | DNMBP-AS1 | DNMBP antisense RNA 1 | 0.27 | 0.30 |
| 2 | DNAJB8-AS1 | DNAJB8 antisense RNA 1 | 0.29 | 0.32 |
| 3 | GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.32 | 0.35 |
| 4 | SORBS2 | sorbin and SH3 domain containing 2 | 0.33 | 0.34 |
| 5 | NTM | neurotrimin | 0.33 | 0.36 |
| 6 | ARRDC3-AS1 | ARRDC3 antisense RNA 1 | 0.33 | 0.37 |
| 7 | ARHGAP28 | Rho GTPase activating protein 28 | 0.34 | 0.38 |
| 8 | MAGEA11 | melanoma antigen family A, 11 | 0.34 | 0.37 |
| 9 | LOC93432 | maltase-glucoamylase (alpha-glucosidase) | 0.36 | 0.39 |
| 10 | lnc-OBFC2A-3 | lnc-OBFC2A-3:1 | 0.36 | 0.41 |