Table 2.
Analysis of differential expression of whole blood mRNA in ATB and LTBI patients by dcRT-MLPA method
| mRNA | ATB | LTBI | P value | mRNA | ATB | LTBI | P value | mRNA | ATB | LTBI | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Il4 | 5.52 | 6.73 | < 0.0001 | Sec14l | 2.859 | 3.2 | 0.0592 | Timp2 | 8.155 | 8.266 | 0.5858 |
| Il7r | 9.15 | 8.147 | < 0.0001 | ltf | 7.125 | 6.53 | 0.0761 | Casp8 | 12.26 | 12.36 | 0.6134 |
| Il8 | 9.254 | 9.844 | < 0.0001 | Mmp9 | 6.34 | 6.155 | 0.0969 | Tnfrsf1a | 12.04 | 12.01 | 0.7111 |
| Tnfrsf1b | 9.93 | 10.42 | 0.0001 | Ccr7 | 13.02 | 12.93 | 0.1686 | Ifng | 9.85 | 9.82 | 0.717 |
| Pgm5 | 9.11 | 7.982 | 0.0016 | Bcl2 | 3.825 | 4.19 | 0.2555 | Tgfb1 | 12.68 | 12.68 | 0.7831 |
| Ccl19 | 9.28 | 8.435 | 0.0034 | Cd4 | 5.815 | 5.71 | 0.3819 | Cd8a | 8.735 | 8.66 | 0.8726 |
| Il2ra | 7.445 | 7.784 | 0.0143 | Il6 | 4.472 | 4.1 | 0.4205 | Foxp3 | 11.04 | 10.96 | 0.8905 |
| Marco | 5.98 | 5.44 | 0.0174 | Tnfrsf10c | 10.38 | 10.48 | 0.4313 | Blr1 | 6.32 | 6.336 | 0.9785 |
| Fpr1 | 4.47 | 4.178 | 0.0206 | Fcgr1a | 5.03 | 5.041 | 0.4422 | Cxcl10 | 10.41 | 10.37 | 0.9953 |
The 9 mRNAs in the first column showed significant differences in expression levels between the ATB and LTBI groups. Among them, il7r, pgm5, ccl19, marco, and fpr1 were up-regulated in ATB patients. Il4, il8, tnfrsf1b, and il2ra were up-regulated in LTBI patients
ATB active tuberculosis, LTBI latent tuberculosis infection