Table II.

Effects of chemotherapeutic drugs on mutations at 10 µg/ml.

	Cell proliferation inhibition, %
Mutation	Oxaliplatin	Irinotecan	SN-38	5-FU	P-value
E17K	66.22±0.67	28.56±1.31	30.38±1.09	21.59±0.06	0.019
E49K	78.25±3.30	29.95±0.26	48.68±1.29	24.39±0.55	0.016
L52R	64.48±0.28	31.52±0.23	33.81±1.22	21.52±0.58	0.016
T41A	79.88±0.68	33.83±1.30	41.07±1.71	25.36±0.24	0.016
S45F	90.59±2.42	32.92±1.10	45.18±0.89	33.36±0.54	0.024
S33P	82.25±1.86	34.55±1.20	44.23±1.39	28.89±1.50	0.016

Data are expressed as mean ± standard deviation (n=3). Data are cell proliferation inhibition (%) values obtained when drugs are administered at a dose of 10 µg/ml for 72 h. 5-FU, 5-fluorouracil.