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. 2021 Jan 19;13:7. doi: 10.1186/s13098-021-00625-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Circ-FANCA knockdown promoted proliferation and suppressed apoptosis and inflammation in LPS-treated HK2 cells. a The efficiency of siRNA-mediated circ-FANCA knockdown was examined by qRT-PCR in LPS-treated HK2 cells. b Cell viability in HK2 cells treated with different concentrations of LPS for 24 h was measured by CCK-8 assay. HK2 cells were divided into 4 groups: Control, LPS, LPS + si-NC and LPS + si-circ-FANCA. c Cell viability in LPS-treated HK2 cells with different transfection or not was measured by CCK-8 assay. d, e Cell apoptosis and cell period distribution were evaluated through flow cytometry in the above groups. f The release levels of inflammatory cytokines IL-1β and TNF-α were examined via ELISA using corresponding kits. g, h The levels of SOD and MDA in HK2 cells were measured by matched kits to assess oxidative stress. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001