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. 2021 Jan 19;13:7. doi: 10.1186/s13098-021-00625-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Circ-FANCA directly interacted with miR-93-5p. a The complementary sequence between circ-FANCA and miR-93-5p were exhibited. b The overexpression efficiency of miR-93-5p in HK2 cells was evaluated by qRT-PCR. c, d The targeted relationship between circ-FANCA and miR-93-5p was validated by dual-luciferase reporter assay and RIP assay. e The expression level of miR-93-5p in the serums of septic AKI patients (n = 19) and healthy controls (n = 19) was examined by qRT-PCR assay. f Spearman’s correlation coefficient analysis was performed to estimate the correlation between circ-FANCA and miR-93-5p in the serums of septic AKI patients. g The level of miR-93-5p in LPS-stimulated HK2 cells was determined by qRT-PCR assay. h The expression level of circ-FANCA in LPS-induced HK2 cells transfected with circ-FANCA or pCD5-ciR was determined by qRT-PCR assay. i MiR-93-5p level was determined through qRT-PCR in LPS-induced HK2 cells following the transfection of si-NC, si-circ-FANCA, pCD5-ciR or circ-FANCA. **P < 0.01, ***P < 0.001, ****P < 0.0001