Table II.
Immunohistochemical expression of P. gingivalis in samples from 205 patients with oral squamous cell carcinoma according to clinical data and follow-up.
| P. gingivalis | |||
|---|---|---|---|
| Variable | Weak, n (%) | Strong, n (%) | P-value |
| Sex | 0.233 | ||
| Male | 39 (45.3) | 64 (53.8) | |
| Female | 47 (54.7) | 55 (46.2) | |
| Age, years | 0.361 | ||
| <60 | 35 (40.7) | 41 (34.5) | |
| ≥60 | 51 (59.3) | 78 (65.5) | |
| Survival status | <0.001a | ||
| Alive | 75 (87.2) | 72 (60.5) | |
| Dead | 11 (12.8) | 47 (39.5) | |
| Differentiation | <0.001a | ||
| Well | 70 (81.4) | 68 (57.1) | |
| Moderate | 16 (18.6) | 33 (27.7) | |
| Poor | 0 (0.0) | 18 (15.1) | |
| Tobacco consumption | 0.047a | ||
| Yes | 18 (20.9) | 40 (33.6) | |
| No | 68 (79.1) | 79 (66.4) | |
| Alcohol consumption | 0.346 | ||
| Yes | 12 (14.0) | 24 (20.2) | |
| No | 74 (86.0) | 95(79.8) | |
| T stageb | <0.001a | ||
| T1-2 | 73 (84.9) | 62 (52.1) | |
| T3-4 | 13 (15.1) | 57 (47.9) | |
| N stageb | 0.011a | ||
| N0 | 69 (80.2) | 76 (63.9) | |
| N(+) | 17 (19.8) | 43 (36.1) | |
| Clinical stage | <0.001a | ||
| I–II | 63 (73.3) | 48 (40.3) | |
| III–IV | 23 (26.7) | 71 (59.7) | |
| Recurrence | 0.301 | ||
| Yes | 10 (11.6) | 20 (16.8) | |
| No | 76 (88.4) | 99 (83.2) | |
| Periodontal condition | 0.018a | ||
| Well | 52 (60.5) | 52 (43.7) | |
| Poor | 34 (39.5) | 67 (56.3) | |
| Tumor size, cm | 0.007a | ||
| <2.9 | 51 (59.3) | 48 (40.3) | |
| ≥2.9 | 35 (40.7) | 71 (59.7) | |
| Treatment | 0.007a | ||
| None | 2 (2.3) | 11 (9.2) | |
| Surgery | 49 (57.0) | 41 (34.5) | |
| Chemotherapy + radiotherapy | 4 (4.7) | 10 (8.4) | |
| Comprehensive | 31 (36.0) | 57 (47.9) | |
a
P<0.05.
b
According to the 7th American Joint Committee on Cancer/Union for International Cancer Control staging system. P-values were determined using χ2 or Fisher's exact tests. P. gingivalis, Porphyromonas gingivalis.