Table V.
Univariate analysis of Cox risk ratio model regression in 205 patients with oral squamous cell carcinoma.
| Variable | No. of patients (%) | P-value | HR | HR (95% CI) |
|---|---|---|---|---|
| Sex | 0.684 | 0.898 | 0.535–1.507 | |
| Male | 103 (50.2) | |||
| Female | 102 (49.8) | |||
| Age, years | 0.023a | 0.503 | 0.277–0.911 | |
| <60 | 76 (37.1) | |||
| ≥60 | 129 (62.9) | |||
| Clinical stage | 0.502 | 1.194 | 0.711–2.006 | |
| I–II | 111 (54.1) | |||
| III–IV | 94 (45.9) | |||
| Tumor size, cm | 0.027a | 0.820 | 0.069–1.097 | |
| <2.9 | 99 (48.3) | |||
| ≥2.9 | 106 (51.7) | |||
| BMI | 0.003a | 0.453 | 0.270–0.761 | |
| <22.5 | 72 (35.1) | |||
| ≥22.5 | 133 (64.9) | |||
| Tobacco consumption | 0.941 | 1.022 | 0.579–1.803 | |
| No | 147 (71.7) | |||
| Yes | 58 (28.3) | |||
| Alcohol consumption | 0.019a | 0.511 | 0.231–1.134 | |
| No | 169 (82.4) | |||
| Yes | 36 (17.6) | |||
| Recurrence | <0.001a | 0.801 | 0.587–1.939 | |
| No | 175 (85.4) | |||
| Yes | 30 (14.6) | |||
| T stageb | 0.132 | 1.501 | 0.884–2.547 | |
| T1-2 | 135 (65.9) | |||
| T3-4 | 70 (34.1) | |||
| N stageb | 0.847 | 1.059 | 0.594–1.888 | |
| N0 | 145 (70.7) | |||
| N1-3 | 60 (29.3) | |||
| Neck dissection | 0.003a | 2.206 | 0.495–0.858 | |
| None | 88 (42.9) | |||
| Yes | 117 (57.1) | |||
| Periodontal condition | 0.636 | 1.133 | 0.676–1.898 | |
| Poor | 101 (49.3) | |||
| Well | 104 (50.7) | |||
| P. gingivalis | <0.001a | 0.260 | 0.135–0.503 | |
| Weak | 86 (42.0) | |||
| Strong | 119 (58.0) | |||
| CXCL2 | <0.001a | 0.283 | 0.156–0.514 | |
| Weak | 99 (48.3) | |||
| Strong | 106 (51.7) | |||
| TANs | 0.013a | 0.494 | 0.283–0.862 | |
| Weak | 95 (46.3) | |||
| Strong | 110 (53.7) |
a
P<0.05.
b
According to the 7th American Joint Committee on Cancer/Union for International Cancer Control staging system. P-values were obtained using a Cox risk ratio regression model. CI, confidence interval; HR, hazard ratio; CXCL2, C-X-C motif chemokine; TANs, tumor-associated neutrophils; P. gingivalis, Porphyromonas gingivalis.