Table 2.
Top ten proteins with the most statistically significant associations (the lowest BH-FDR adjusted p-values) for the interaction between temperature and hold time in multi-donor blood processing study
| Accession | Description | logFC | AveExpr | BH-FDR |
|---|---|---|---|---|
| P02788 | LTF: lactotransferrin | − 1.03 | 7.29 | 0.0019 |
| O14511-2 | NRG2: Isoform 2 Of Pro-Neuregulin-2, membrane-bound isoform | − 0.78 | 7.36 | 0.0022 |
| P23528 | CFL1: cofilin-1 | − 0.67 | 6.59 | 0.0033 |
| P52209-2 | PGD: isoform 2 of 6-phosphogluconate dehydrogenase, decarboxylating | − 0.97 | 6.31 | 0.0090 |
| P06744 | GPI: glucose-6-phosphate isomerase | − 0.93 | 6.29 | 0.0090 |
| P30740 | SERPINB1: leukocyte elastase inhibitor | − 0.93 | 6.16 | 0.0115 |
| P04083 | ANXA1: annexin A1 | − 0.82 | 6.31 | 0.0115 |
| P00558-2 | PGK1: isoform 2 of phosphoglycerate kinase 1 | − 0.95 | 6.66 | 0.0187 |
| P02655 | APOC2: apolipoprotein C-II | − 0.23 | 9.87 | 0.0211 |
| P02730 | SLC4A1: band 3 anion transport protein | − 1.02 | 6.15 | 0.0211 |
Column “logFC” represents estimated fold change on log base 2 scale due to one day delay in processing at 4C, as compared to room temperature (shown in Table 1). Negative sign for “logFC” indicates lower rate of change with time at lower temperature. Column “AveExpr” represents average expression level of each protein on the scale of log base 2 CPM (as further explained in Additional file 1: Section S1)