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. 2021 Jan 20;27(2):1149–1166. doi: 10.1007/s10989-020-10157-w

Table 1.

A Selection of MHC-I epitopes (derived from B-cell epitopes) based on VaxiJen score > 1

Protein name B-cell epitope sequence MHC-I epitope sequence MHC-I binding alleles VaxiJen score
A
 HpaA NPSVETKTQNDAKNQQPVQTHERMKTSSEHVTPLDFNYPIHIVQAPQN HVTPLDFNYP

HLA-A*0201

HLA-A*0205

HLA-B*2702

HLA-B*3501

HLA-B*3701

HLA-B*3801

HLA-B*0702

1.1099
GYQVLRFQDEKALSAQDKR QDEKALSAQ

HLA-A*1101

HLA-A*3101

HLA-B*2702

HLA-B*5801

1.1087
PESNRVVHDFAVEVG VVHDFAVEV

HLA-A*0201

HLA-A*0205

HLA-B*3701

HLA-B*4403

HLA-B*5301

1.3684
YTYKHSNSGGLDSSNNIIHEALEKNKEDA KHSNSGGLD

HLA-B*3902

HLA-B*5301

HLA-B*5401

2.2506
 FlaA NALKTSLERLSSGLRINKAAD RLSSGLRIN

HLA-B*2702

HLA-B*2705

HLA-B*3901

HLA-B*5801

1.5169
AAQDGQTTESRKAIQSD QDGQTTESR

HLA-B*2702

HLA-B*5101

HLA-B*5801

2.9528
VTGNFNANVKSASGANYNAVIASGNQSLGSGVTTLRG NANVKSASG HLA-B*5401 2.2390
VNNISITQVNVKAAESQIRDV VNVKAAESQ HLA-B*5801 1.9766
 FlaB QNNRDLSSSLEKLSSGLRINKAADD KLSSGLRIN

HLA-A*0205

HLA-B*3901

HLA-B*5801

1.5519
AQDGQTLESRRALQSDIQRLLEE QDGQTLESR

HLA-A*3302

HLA-B*2702

HLA-B*3501

HLA-B*3902

HLA-B*5801

2.2153
VRGIFDANVASAAGANANGAQAETNSQGIGAGVTSLKGAM NANGAQAET

HLA-B*5101

HLA-B*5103

2.4424
ISVTQVNVKAAESQIRDVDF VNVKAAESQ HLA-B*5801 1.9766
 Omp18 HKMDNKTVAGDVSAKTVQTAPVTTEPAPEKEEPKQEPAPVVEEKPAVESGT GDVSAKTVQ

HLA-A*3302

HLA-B*5101

HLA-B*5102

HLA-B*5103

HLA-B*5201

HLA-B*5801

1.9177
HKMDNKTVAGDVSAKTVQTAPVTTEPAPEKEEPKQEPAPVVEEKPAVESGT EKEEPKQEP

HLA-B*4403

HLA-B*0702

1.3706
FDFDKYEIKESDQET EIKESDQET

HLA-A*3302

HLA-B*3701

HLA-B*3901

HLA-B*3902

HLA-B*4403

HLA-B*5301

1.8008
ISFGETKPKCTQKTRECYKEN GETKPKCTQ

HLA-A*1101

HLA-A*3101

HLA-B*5401

HLA-B*5801

1.7641
Sl. No B-cell epitope sequence MHC-II epitope sequence MHC-II binding alleles VaxiJen score
B
 HpaA NPSVETKTQNDAKNQQPVQTHERMKTSSEHVTPLDFNYPIHIVQAPQN VQTHERMKTSSEHVT

HLA-DRB1*1302

HLA-DRB1*0901

HLA-DRB1*0701

HLA-DRB1*0301

HLA-DRB1*0405

1.2231
NPSVETKTQNDAKNQQPVQTHERMKTSSEHVTPLDFNYPIHIVQAPQN PSVETKTQNDAKNQQ

HLA-DRB1*0802

HLA-DRB1*1302

HLA-DRB4*0101

HLA-DRB3*0101

1.6689
GYQVLRFQDEKALSAQDKR LRFQDEKALSAQDKR

HLA-DRB1*0401

HLA-DQA1*0401

HLA-DPA1*0103

HLA-DRB5*0101

1.1177
YTYKHSNSGGLDSSNNIIHEALEKNKEDA YTYKHSNSGGLDSSN

HLA-DRB1*0101

HLA-DQA1*0501

HLA-DRB1*0401

HLA-DRB3*0101

HLA-DRB1*0405

1.3437
 FlaA AAQDGQTTESRKAIQSD QDGQTTESRKAIQSD

HLA-DQA1*0301

HLA-DQA1*0102

HLA-DQA1*0401

HLA-DRB1*0701

HLA-DQA1*0501

1.7622
VTGNFNANVKSASGANYNAVIASGNQSLGSGVTTLRG ASGNQSLGSGVTTLR

HLA-DQA1*0301

HLA-DPA1*0301

HLA-DRB1*0405

HLA-DQA1*0501

HLA-DPA1*0201

1.3656
VTGNFNANVKSASGANYNAVIASGNQSLGSGVTTLRG NANVKSASGANYNAV

HLA-DRB1*1101

HLA-DRB3*0101

HLA-DQA1*0301

HLA-DQA1*0501

HLA-DPA1*0103

1.6352
VNNISITQVNVKAAESQIRDV NISITQVNVKAAESQ

HLA-DQA1*0101

HLA-DRB3*0101

1.6160
 FlaB AQDGQTLESRRALQSDIQRLLEE QDGQTLESRRALQSD

HLA-DRB1*1101

HLA-DQA1*0102

HLA-DRB1*0802

HLA-DRB1*0301

HLA-DRB1*0901

1.2748
VRGIFDANVASAAGANANGAQAETNSQGIGAGVTSLKGAM ETNSQGIGAGVTSLK

HLA-DQA1*0102

HLA-DQA1*0301

HLA-DRB1*0101

HLA-DQA1*0401

HLA-DRB1*0301

1.7236
VRGIFDANVASAAGANANGAQAETNSQGIGAGVTSLKGAM GANANGAQAETNSQG

HLA-DRB1*0401

HLA-DQA1*0501

HLA-DRB1*0405

HLA-DRB4*0101

HLA-DPA1*0103

2.3765
ISVTQVNVKAAESQIRDVDF QVNVKAAESQIRDVD

HLA-DPA1*0103

HLA-DQA1*0101

HLA-DRB1*1201

HLA-DRB1*1501

HLA-DPA1*0301

1.6015
 Omp18 HKMDNKTVAGDVSAKTVQTAPVTTEPAPEKEEPKQEPAPVVEEKPAVESGT KMDNKTVAGDVSAKT

HLA-DQA1*0501

HLA-DRB1*0401

HLA-DRB1*0802

HLA-DRB3*0101

HLA-DRB1*0301

1.7244
HKMDNKTVAGDVSAKTVQTAPVTTEPAPEKEEPKQEPAPVVEEKPAVESGT NKTVAGDVSAKTVQT

HLA-DQA1*0401

HLA-DRB1*0802

HLA-DQA1*0301

HLA-DRB1*0901

HLA-DRB1*1302

1.4458
FDFDKYEIKESDQET FDFDKYEIKESDQET

HLA-DPA1*0201

HLA-DPA1*0103

HLA-DRB1*0401

HLA-DRB1*0301

HLA-DRB4*0101

1.3271
ISFGETKPKCTQKTRECYKEN GETKPKCTQKTRECY

HLA-DRB1*0301

HLA-DRB1*1201

HLA-DRB1*1101

HLA-DRB1*0701

HLA-DRB5*0101

1.3419