Fig. 6.

Photomicrograph of the heart ventricle (A & B): Control group showing normal cardiac muscle fibers with acidophilic cytoplasm and oval, large pale nuclei (N). Some cardiomyocytes are binuclear (BI). Myofibers are arranged in bundles with narrow spaces in between (S) and connected with intercalated discs (arrows). (C & D): Azithromycin group showing areas of severe degeneration in cardiac muscle fibers (arrows), pyknotic nuclei (PN), distortion of the typical arrangement of myofibers with massive wide spaces (S), and hemorrhage (Hge).

(E): Azithromycin + Rosuvastatin group showing the restored arrangement of cardiac muscle fibers with narrow spaces in between (S). Ventricle cavity (CA). A, C, D, E (H&E; ×400) and B (H&E; ×1000).