Fig. 3.

Scheme of the SARS-CoV-2 Variome Structure-Substrate Database. This is an interactive database. The database will collect and update all mutations for three key viral proteins in the SARS-CoV-2 genome. Users can explore and predict protein conformational changes of mutants, and to visualize changes in enzyme activities or antigen–antibody affinities of mutants for three key viral proteins, using computational modeling and machine learning approaches. Finally, users can evaluate potential effects of mutants on U.S. FDA regulated antibody and chemical drugs.