Table 3.
IC50 values of seven individual herbs for preparing Qingfei Paidu decoction with strong CYP3A inhibition activities.
| Herbs | Dose (g) | Extraction rate (%) | Time-dependent inhibitiona IC50 (μg/mL) |
Ratio | |
|---|---|---|---|---|---|
| Pre-incubation for 3 min | Pre-incubation for 33 min | ||||
| Herba Ephedrae | 9 | 11.6 | 55.8 ± 12.9 | 34.1 ± 6.7 | 1.64 |
| Radix Glycyrrhizae Praeparata | 6 | 18.5 | 157.7 ± 7.1 | 150.3 ± 19.3 | 1.05 |
| Radix Scutellariae | 6 | 31.2 | 254.4 ± 38.9 | 141.4 ± 8.7 | 1.80 |
| Fructus Aurantii Immaturus | 6 | 14.5 | 295.9 ± 30.2 | 42.1 ± 4.4 | 7.03 |
| Ramulus Cinnamoni | 9 | 5.1 | 310.7 ± 66.1 | 150.3 ± 24.9 | 2.07 |
| Rhizoma Belamcandae | 9 | 9.8 | 424.1 ± 51.1 | 136.5 ± 16.3 | 3.11 |
| Rhizoma Zingiberis Recens | 9 | 4.2 | 532.8 ± 74.6 | 188.9 ± 23.1 | 2.82 |
a
The IC50 values were determined in HLM following short (3 min) or long (33 min) pre-incubation.