Fig. 2.

(A) HR of invasive mechanical ventilation (IMV)^a/death associated with sex overall and in subsets from fitting a standard unadjusted Cox regression model. ^aDefinition: Indication for IMV were neurologic failure (i.e. altered consciousness with a Glasgow Coma Scale score <10), cardiovascular failure (i.e. vasopressor requirement or major ECG changes including arrhythmia or changes in repolarization phase) and respiratory failure defined by the presence of at least two of the following criteria: respiratory rate >30 bpm, respiratory distress with activation of accessory respiratory muscles, need for FiO₂ at 80% or more to maintain an SaO₂ level at 90%, or a PaO₂/FiO₂ <100 mm [23]. (B) HR of death associated with sex overall and in subsets from fitting a standard unadjusted Cox regression model.