Table 4.
Mediation analysis. Risk of invasive mechanical ventilation/death for female vs. male
| Direct effect |
Indirect effect |
Percentage of total effect mediated | |||||
|---|---|---|---|---|---|---|---|
| % | 95% CI | % | 95% CI | ||||
| Biomarker (per log10 higher) | |||||||
| Total lymphocytes, AUC | –11 | –21%; 0% | 0 | –2%; +2% | 0.5 | ||
| Alanine amino-transferase, AUC | –15 | –24%; –5% | +2 | 0%; +5% | –18 | ||
| D-dimer, AUC | –13 | –22%; –3% | –0.4 | –1%; 0% | 3 | ||
| Lactate dehydrogenase, AUC | –7 | –16%; +3% | –5 | –10%;–1% | 43 | ||
| C-reactive protein, AUC | –2 | –11%; +8% | –10 | –16%; –6% | 85 | ||
| C-reactive protein, peak | –7 | –16%; +3% | –7 | –12%; –4% | 53 | ||
| Platelets, AUC | –12 | –21%; –2% | –2 | –5%; –1% | 16 | ||
| IL-6, AUC | –16 | –26%; –5% | –4 | –8%; 0% | 18 | ||
| Ferritin, AUC | –4 | –16%; +8% | –5 | –10%; 0% | 47 | ||
| Haemoglobin, AUC | –19 | –27%; –1% | +1 | 0%; +5% | –10 | ||
| Use of steroids, yes/no | –9 | –18%; 0% | –3 | –8%; 0% | 27 | ||