Table 5.
Mediation analysis. Risk of death for female vs. male
| Direct effect |
Indirect effect |
Percentage of total effect mediated | |||
|---|---|---|---|---|---|
| % | 95% CI | % | 95% CI | ||
| Biomarker (per log10 higher) | |||||
| Total lymphocytes, AUC | –6 | –16%; +5% | 0 | –1%; +2% | 0.5 |
| Alanine amino-transferase, AUC | –4 | –15%; +8% | –2 | –4%; 0% | 19 |
| D-dimer, AUC | –9 | –16%; 0% | –1 | –0.3%; 0% | 14 |
| Lactate dehydrogenase, AUC | –3 | –11%; +6% | –6 | –10%;–2% | 64 |
| C-reactive protein, AUC | –2 | –10%; +6% | –7 | –12%; –4% | 78 |
| C-reactive protein, peak | –3 | –10%; +5% | –9 | –13%; –5% | 74 |
| Platelets, AUC | –8 | –16%; 0% | 0 | –3%; –1% | 10 |
| IL-6, AUC | –11 | –20%; 0% | –4 | –5%; 0% | 16 |
| Ferritin, AUC | 0 | –10%; +12% | –4 | –10%; –1% | 62 |
| Haemoglobin, AUC | –11 | –19%; –2% | +2 | 0%; +5% | –28 |
| Use of steroids, yes/no | –7 | –15%; 0% | –1 | –3%; 0% | 12 |