Skip to main content
. Author manuscript; available in PMC: 2021 Jan 20.
Published in final edited form as: Clin Pharmacol Ther. 2020 Jan 30;107(6):1383–1393. doi: 10.1002/cpt.1751

Figure 3.

Figure 3

LocusZoom plots of cis-eQTLs (expression quantitative trait loci) in DPYD, PCSK9, and GPR180. (a) DPYD: rs59353118 (located in DPYD intron 14), rs75017182 (a splice variant in the HapB3 haplotype), and p53 transcription factor binding motif. (b) Two sex-biased cis-eQTLs in PCSK9: rs12145732 (r2 = 0.8 with rs114525994) is located ~ 450 kb 5′ of PCSK9 and predicted to alter FOXA transcription factor binding; FOXA transcription factor binding motif. (c) GPR180: rs9561643 is located ~ 1 kb 5′ of GPR180 and colocalized with rs2298058, a MVP (Million Veteran Program) GWAS (genome-wide association study) variant associated with blood triglyceride levels. chr, chromosome; FOXA, forkhead box protein A; Mb, megabase.