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. 2020 Sep 30;24(1):64–76. doi: 10.1093/ijnp/pyaa076

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© The Author(s) 2020. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Chronic constriction injury (CCI) surgery induced activation of the hippocampal NLRP3 inflammasome. (A) Representative Western blot bands of NLRP3 and caspase-1 (p20). Quantitative analysis of western-blot expression of NLRP3 (B) and caspase-1 (C) in sham-operated and CCI-operated rats. The fold change in the protein band density was normalized to that of β-actin, and the results are presented as fold change from the sham group (n = 3 rats/group). Activity of caspase-1 (D) and levels of interleukin (IL)-1β (E) in the hippocampus (n = 5 rats/group). Data are expressed as the mean ± SD; *P < .05, **P < .01, and ***P < .001 compared with sham group. Double-immunofluorescence representative photomicrographs displaying the cellular localization of NLRP3 (red) and NeuN (green) (F, G) and caspase-1 (red) and NeuN (green) (H, I) on day 29 after CCI. Photomicrographs are of the hippocampus of rats with CCI.