Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Thum and co-workers6 show that inhibition of miR-132, which is expressed from the miR-212-132 locus on human chromosome 17, results in increased levels of FoxO3 and Serca2a and improved cardiac function. Inhibition is achieved by administering a chemically modified oligonucleotide (CDR132L), which contains locked nucleic acid (LNA) nucleotides and phosphonothioate (PS) linkages to increase in vivo stability.
