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. 2020 Jun 4;24(1):54–63. doi: 10.1093/ijnp/pyaa040

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© The Author(s) 2020. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Effects of an orexin-1 receptor antagonist (SB) on demand and motivation for palatable foods in both sexes. Across both male and female rats, SB reduced low (Q₀, panel a) and high cost (α, panel b) responding for low-fat palatable reward (LFP). In rats tested on behavioral-economic (BE) for high-fat palatable reward (HFP), SB reduced low- (Q₀, panel c), but not high-cost (α, panel d) responding in both male and female rats. When tested on chocolate sucrose palatable reward (CSP), SB reduced low- (Q₀, panel e) and high-cost (α, panel f) responding in both males and females; posthoc analyses revealed that α values were significantly higher (motivation was lower) following SB in males compared with females (P = .0017). **P < .01, ***P < .001, ****P < .0001.