Figure 9.

CP@NP‐cRGD induced more apoptosis and less proliferation by inhibiting protective autophagy in AZD9291‐resistant NSCLC in vivo. A) Tumor biopsies were stained with H&E, LC3B, cleaved caspase3, Ki67. The upper panels showed H&E results with 100‐fold magnification, and the lower panels showed IHC results with 200‐fold magnification. B) Apoptosis evaluation by TUNEL assay, representative TUNEL images with 200‐fold magnification and percentage of TUNEL‐positive cells. Scale bar: 100 µm. C) Representative electron microscopy images and quantitative analysis of autophagosomes (red) and autolysosomes (green) of tissue samples exacted from tumor xenografts.