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. 2021 Jan 16;9(1):coaa136. doi: 10.1093/conphys/coaa136

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© The Author(s) 2021. Published by Oxford University Press and the Society for Experimental Biology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Functional interactions between genes under positive selection in the SIRT signaling pathway (ingenuity pathway analysis, IPA). Genes with functionally relevant amino-acid substitutions (PROVEAN score ≤ −2.5) coloured in yellow. Possible downstream damaging effects of these genes were visualized using the molecule activity predictor (MAP) tool in IPA (see prediction legend). These highlight changes to gluconeogenesis and fatty acid oxidation.