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Functional interactions between genes under positive selection in the mTOR signaling pathway (ingenuity pathway analysis, IPA). Genes with functionally relevant amino-acid substitutions (PROVEAN score ≤ −2.5) coloured in yellow. Possible downstream damaging effects of these genes were visualized using the molecule activity predictor (MAP) tool in IPA (see prediction legend). These highlight important changes to key biological decisions about energetic investment.
