TABLE 3.
Cox regression analysis of the association between PVC burden and complexity and outcomes in two groups
| Idiopathic | Structural heart disease | |||||||
|---|---|---|---|---|---|---|---|---|
| Unadjusted | Adjusted | Unadjusted | Adjusted | |||||
| HR (95% CI) | p‐value | HR (95% CI) | p‐value | HR (95% CI) | p‐value | HR (95% CI) | p‐value | |
| All‐cause death | ||||||||
| PVC% | 0.960 (0.912–1.011) | .119 | — | 0.944 (0.899–0.992) | .023 | 0.951 (0.905–1.000) | .048 | |
| PVC% per quartile | ||||||||
| Quartile 1 | Reference | Reference | Reference | Reference | ||||
| Quartile 2 | 1.733 (0.806–3.728) | .159 | — | 0.629 (80.335–1.181) | .149 | — | ||
| Quartile 3 | 2.331 (1.090–4.984) | .029 | 2.288 (1.042–5.026) | .039 | 0.645 (0.351–1.187) | .159 | — | |
| Quartile 4 | 1.247 (0.426–2.553) | .611 | — | 0.384 (0.191–0.772) | .007 | 0.417 (0.203–0.858) | .017 | |
| Polymorphic | 1.713 (0.952–3.085) | .073 | — | 1.275 (0.707–2.296) | .419 | — | ||
| Triplets | 1.982 (1.173–3.350) | .011 | 1.289 (0.740–2.245) | .370 | 1.117 (0.702–1.779) | .641 | — | |
| NSVT | 2.162 (1.149–4.070) | .017 | 1.898 (0.984–3.662) | .056 | 1.033 (0.621–1.717) | .902 | — | |
| All‐cause death or CV hospitalizations | ||||||||
| PVC% | 0.973 (0.931–1.016) | .210 | — | 0.960 (0.921–1.001) | .055 | — | ||
| PVC% per quartile | ||||||||
| Quartile 1 | Reference | Reference | Reference | |||||
| Quartile 2 | 1.659(0.840–3.276) | .145 | — | 0.594 (0.333–1.062) | .079 | — | ||
| Quartile 3 | 1.796 (0.891–3.618) | .101 | — | 0.572 (0.325–1.007) | .053 | — | ||
| Quartile 4 | 1.035 (0.493–2.176) | .927 | — | 0.462 (0.250–0.856) | .014 | 0.484 (0.257–0.911) | .025 | |
| Polymorphic | 1.785 (1.031–3.093) | .039 | 1.222 (0.679–2.201) | .504 | 1.075 (0.637–1.816) | .786 | — | |
| Triplets | 1.867 (1.145–3.045) | .012 | 1.004 (0.970–1.040) | .498 | 0.999 (0.651–1.5349 | .997 | — | |
| NSVT | 1.724 (0.926–3.211) | .086 | — | 1.006 (0.632–1.603) | .980 | — | ||
| HF death or HF hospitalizations a | ||||||||
| PVC% | — | 0.989 (0.913–1.072) | .796 | — | ||||
| PVC% per quartile | ||||||||
| Quartile 1 | Reference | Reference | ||||||
| Quartile 2 | — | 1.345 (0.301–6.014) | .698 | — | ||||
| Quartile 3 | — | 1.217 (0.272–5.449) | .798 | — | ||||
| Quartile 4 | — | 1.265 (0.282–5.666) | .759 | — | ||||
| Polymorphic | — | 4.086 (0.531–31.47) | .176 | — | ||||
| Triplets | — | 2.757 (0.942–8.069) | .064 | — | ||||
| NSVT | — | 1.620 (0.576–4.551) | 0.360 | — | ||||
| Sudden death or hospitalization due to VA | ||||||||
| PVC% | 0.817 (0.546–1.220) | .323 | — | 0.980 (0.872–1.102) | .736 | — | ||
| PVC% per quartile | ||||||||
| Quartile 1 | Reference | Reference | Reference | Reference | ||||
| Quartile 2 | 0.469 (0.043–5.174) | .536 | — | 0.246 (0.028–2.204) | .210 | — | ||
| Quartile 3 | 1.144 (80.161–8.137) | .893 | — | 0.223 (0.025–2.004) | .181 | — | ||
| Quartile 4 | 0.013 (000–1,209) | .459 | — | 0.430 (0.078–2.357) | .331 | — | ||
| Polymorphic | 44 (0.025–7,766) | .319 | — | 1.046 (0.211–5.187) | .956 | — | ||
| Triplets | 2.315 (0.387–13.86) | .358 | — | 0.188 (0.023–1.524) | .117 | — | ||
| NSVT | 2.498 (0.279–22.41) | .413 | — | 4.345 (1.037–18.20) | .044 | 3.896 (0.903–16.81) | .068 | |
Abbreviations: AF, atrial fibrillation; CV, cardiovascular; LAD, left atrium diameter; LVFS, left ventricular fractional shortening; NSVT, non‐sustained ventricular tachycardia; PVCs, premature ventricular contractions; SV, supraventricular; VA, ventricular arrhythmias.
The analysis of the combined outcome of HF death or HF hospitalizations the analysis was only done in the SHD group because there was only 1 event in the idiopathic group. In multivariable analysis, only covariables with a p < .05 in univariable analysis were included (Table S3), respectively: for all‐cause mortality, the covariables included were age, presence of supraventricular runs, presence of episodes of AF, LAD, and LVFS; for the combined outcome of all‐cause mortality and CV hospitalizations, the covariables included were age, gender, presence of episodes AF, LAD, and LVFS; for the combined outcome of sudden death or VA hospitalization, the only significant covariable included was LAD.