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. 2021 Jan 18;9(1):e001932. doi: 10.1136/jitc-2020-001932

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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ERβ signaling promotes CD8⁺ T cell activation. (A) IP-Western blot of pY36 (top) and total ERβ (bottom) from mouse primary CD8⁺ T cells with/without anti-CD3/CD28 treatment for the indicated time period. (B) ELISA measurement of cytokine production by purified CD8⁺ T cells from male WT or KI mice, with or without stimulation by anti-CD3/CD28. (C) CD8⁺ T cells from male WT or KI mice were stimulated with anti-CD3/CD28 antibodies for indicated time period and probed for phospho- (p-) and total proteins by immunoblotting. α-tubulin was used as a loading control. IFNγ, interferon-γ; IL2, interleukin 2; KI, knock-in; TNFα, tumor necrosis factor alpha; WT, wild-type.