Fig 8. MCL-1 inhibitor treatment prevents KSHV⁺ BCBL-1-mediated tumor formation in NOD/SCID mice.

(A) BCBL-1 cells were injected intraperitoneally into NOD/SCID mice, followed by treatment with AT-101 once a week. Mice were euthanized using CO₂ at 6 weeks after cell injection. Animals treated with AT-101 did not develop the distention observed in vehicle-treated animals. (B) After 28 days, mice were sacrificed and the volume of ascites fluid was measured. The number of dots in ascites volume represents the number of sacrificed mice. Error bars represent the SEM for two independent experiments. ***, p < 0.0005. (C) Body weight of DMSO or AT101 treated mice was recorded daily. p = 0.001 (D) The spleens in AT-101-treated animals were smaller than those in vehicle-treated animals.