Fig 2. Viral load (VL) characteristics (from measured data, Fig 1) by inoculum dose (log₁₀ PFU, x-axis) and viral strain (indicated by markers, BR: green triangles, PR: purple circles).

Correlations between inoculum dose and VL characteristics are tested by Pearson correlation for each strain separately, and where this is found to be significant at the α = 0.05 level after Bonferroni correction for multiple testing (m = 6) the linear regression line is shown in the panel, and the p-value and correlation coefficient are shown in the legend. Differences in VL characteristics between viral strains for each inoculum group are tested with the Mann-Whitney U test, and none are found to be significant at the α = 0.05 level after Bonferroni correction for multiple testing (m = 6). The day 1 VL, time of peak VL and value of peak VL are the observed measurements. The area under the curve (AUC) of the log₁₀ plasma VL and the downslope of the log₁₀ plasma VL are calculated as described in the methods. Animals with VL data only to day 7 or which do not have any undetectable VLs after the peak are excluded from the analysis of “time of first undetectable plasma VL”.