Table 1. Baseline demographic and clinical characteristics.
| Total n = 755 | Ipc-PH n = 641 | Cpc-PH n = 114 | p value | |
|---|---|---|---|---|
| Age (years) | 60 ± 15 | 59 ± 15 | 62 ± 14 | 0.03 |
| Males | 307 (41%) | 266 (41%) | 41 (36%) | NS |
| Art. Hypertension | 431 (57%) | 356 (56%) | 75 (62%) | NS |
| Stroke/Systemic embolism | 56 (7%) | 43 (7%) | 13 (11%) | NS |
| Diabetes mellitus | 215 (28%) | 172 (27%) | 43 (38%) | 0.02 |
| Specific therapy | 475 (61%) | 404 (63%) | 71 (62%) | NS |
| NYHA (class) | ||||
| • I | 7 (1%) | 6 (1%) | 1 (1%) | NS |
| • II | 138 (18%) | 125 (20%) | 13 (11%) | 0.023 |
| • III | 500 (66%) | 417 (65%) | 83 (73%) | NS |
| • IV | 107 (14%) | 90 (14%) | 17 (15%) | NS |
| • III and IV | 607 (70%) | 507 (79%) | 100 (88%) | 0.026 |
| 6MWT (meters) | 321 ± 122 | 325 ± 123 | 298 ± 111 | 0.047 |
| LA in PLAX (mm) | 41 ± 8 | 41 ± 7 | 45 ± 8 | < 0.0001 |
| LV EF (%) | 63 ± 8 | 63 ± 8 | 68 ± 8 | NS |
| LVEDD in PLAX (mm) | 46 ± 8 | 45 ± 8 | 47 ± 7 | 0.02 |
| RA in A4C (mm) | 47 ± 11 | 47 ± 11 | 48 ± 11 | NS |
| RV in A4C (mm) | 44 ± 10 | 44 ± 10 | 45 ± 10 | NS |
| TAPSE (mm) | 18 ± 5 | 19 ± 5 | 17 ± 5 | 0.02 |
| PAMP (mmHg) | 48 ± 16 | 47 ± 16 | 52 ± 15 | 0.003 |
| PAWP (mmHg) | 12 ± 5 | 10 ± 3 | 19 ± 2 | < 0.0001 |
| RAP (mmHg) | 10 ± 6 | 9 ± 5 | 15 ± 6 | < 0.0001 |
| Follow-up (years) | 3.8 ± 2.8 | 3.8 ± 2.8 | 3.7 ± 2.6 | NS |
| Dead | 415 (55%) | 341 (53%) | 74 (65%) | 0.02 |
| SVT prevalence | 220 (29%) | 162 (25%) | 58 (51%) | < 0.0001 |
Values are expressed as mean ± standard deviation or as n (%). NS–non-significant. Ipc-PH–isolated pre-capillary pulmonary hypertension; Cpc-PH–combined post- and pre-capillary pulmonary hypertension; PH–pulmonary hypertension; 6MWT–six minute walking test; LA–left atrium; LV–left ventricle; EF–ejection fraction; LVEDD–left ventricular end-diastolic diameter; RA–right atrium; RV–right ventricle; TAPSE–tricuspid annular plane systolic excursion; PAMP–pulmonary arterial mean pressure; PAWP–pulmonary arterial wedge pressure; RAP–right atrial pressure; SVT–supraventricular tachycardia; PLAX–parasternal long axis view; A4C –apical four chamber view.