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. 2020 Dec 31;16(12):e1009067. doi: 10.1371/journal.ppat.1009067

Fig 5. Growth features of ΔTgPiT in vivo.

Fig 5

The acute virulence of ΔTgPiT parasites was evaluated in a murine model via two routes of infections. A. 150 parasites from each strain or PBS alone were used to infect intravenously outbred mice (n = 5 mice for each strain), and the mortality (panel a) and weight (panel b) of the mice were monitored daily. Panel c shows a magnified view of each plaque assay in which monolayers of fibroblasts were infected with 150 parasites for 5 days. *, p = 0.0024; **, p<0.0001 (Log-rank Mantel-Cox test). B. 50 parasites from each strain or PBS alone were used to infect subcutaneously outbred mice (n = 6 mice for each strain) to monitor the mortality (panel a) and weight (panel b) of the mice. Note that Y axis starts at 50% for better representation of the data for each group. Plaque assays on infected fibroblasts with 50 parasites for 9 days are shown in panel c. *, p = 0.0496; **, p<0.0001 (Log-rank Mantel-Cox test).