Fig. 3.
Significantly greater expression of PD-1, PD-L1, and CD4 are observed in iLTS and iSGS patients compared to controls. Quantification of IHC staining demonstrates (A) significantly greater expression of PD-1 in iLTS and iSGS patients compared to controls and (B) significantly greater expression of PD-L1 in iLTS and a trend toward greater expression of PD-L1 in iSGS patients compared to control. (C) CD4 expression is significantly elevated in iLTS and iSGS patients compared to controls. No significant differences were observed between iLTS and iSGS patient groups. (D) CD8 expression was not significantly different between iLTS patients and controls and was not evaluated in iSGS due to sample availability. iLTS = iatrogenic laryngotracheal stenosis; iSGS = idiopathic subglottic stenosis; PD-1 = programmed death-1; PD-L1 = programmed death-ligand 1.