Table 4.
Univariate and Multivariate Analysis
| Primary Composite Safety Outcome Met (n = 17) | Primary Composite Safety Outcome Not Met (n = 77) | Univariate OR (CI) | P Value | Multivariate OR (CI) | P Value | |
|---|---|---|---|---|---|---|
| CTX | 9 (52.9) | 55 (71.4) | 0.45 (0.154–1.316) | .139 | 0.53 (0.144–1.957) | .342 |
| Duration of treatment arm ≥4 wk | 14 (82.4) | 52 (67.5) | 2.24 (0.590–8.526) | .227 | 1.84 (0.433–7.776) | .410 |
| Source removal | 2 (11.8) | 26 (33.8) | 0.26 (0.056–1.231) | .073 | 0.13 (0.021–0.822) | .030 |
| Coronary artery disease | 1 (5.9) | 18 (24) | 0.2 (0.025–1.598) | .181 | 0.10 (0.010–1.126) | .063 |
| Gentamicin ≥2 wk duration | 4 (23.5) | 6 (7.8) | 3.64 (0.901–14.713) | .078 | 6.55 (0.893–48.106) | .065 |
| Congestive heart failure | 3 (17.6) | 20 (26) | 0.59 (0.153–2.268) | .547 | - | - |
| Endocarditis | 10 (52) | 48 (62) | 0.86 (0.296–2.517) | .787 | - | - |
| CCI, median (IQR) | 4 (3–4.5) | 4 (2–5) | - | .784 | - | - |
| PBS, median (IQR) | 1 (0–2) | 0 (0–2) | - | .781 | - | - |
| Age ≥65 y | 8 (47.1) | 46 (59.7) | 0.60 (0.208–1.722) | .338 | - | - |
| S. mitis | 6 (37.5) | 23 (29.9) | 1.41 (0.458–4.333) | .563 | - | - |
| Infection source identified | 15 (88.2) | 72 (93.5) | 0.54 (0.095–3.028) | .606 | - | - |
| Moderate or severe CKD | 2 (11.8) | 7 (9.1) | 1.33 (0.252–7.065) | .664 | - | - |
All data expressed as No. (%) unless otherwise noted.
Abbreviations: CCI, Charlson comorbidity index; CKD, chronic kidney disease; CTX, ceftriaxone; PBS, Pitt bacteremia score.