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. 2020 Dec 28;118(1):e2020810118. doi: 10.1073/pnas.2020810118

Fig. 7.

Fig. 7.

IL-33/ST2 signaling is important for spatial learning and memory in young adult mice. (A–C) Intracerebroventricular administration of soluble ST2 (sST2) (0.26 ng/h) or human IgG Fc fragment (Con) to 3-mo-old C57 mice via miniosmotic pumps for 9 d impaired spatial learning and memory. Quantitative analysis of the percentage (A) and the number (B) of alternations in the Y-maze test (*P < 0.05, two-tailed unpaired t test; Con: n = 11 mice; sST2: n = 9 mice). (C) Quantitative analysis of the percentage of freezing time 1 d after electric foot shock in the contextual fear conditioning test (**P < 0.01, two-tailed unpaired t test; Con: n = 12 mice; sST2: n = 11 mice). (D and E) sST2 administration did not affect locomotor activity or anxiety-like behavior in 3-mo-old C57 mice in the open field test. (D) Change in distance traveled (Dx) relative to the distance traveled on the first day (D1) of training (percentage). (E) Time spent (percentage) in the inner zones versus outer zones in the first 5 min of open field exploration (n = 10 mice per group). Values are the mean ± SEM.