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. 2020 Dec 28;118(1):e2016605118. doi: 10.1073/pnas.2016605118

Fig. 4.

Fig. 4.

Analysis of pHLIP biodistribution. Model-predicted concentration profiles were generated for wild-type pHLIP after a single i.v. injection of 3 nmol into a mouse. (A) The total concentration, interstitial fluid concentration, and cell-bound concentration of pHLIP relative to total tumor/normal tissue volume (cells + interstitial fluid). (B) The total cell-bound concentration, state 2 concentration, and state 3 concentration of pHLIP relative to tumor/normal tissue cell volume (which excludes the interstitial fluid). (C) The respective tumor:normal tissue ratios. (D) Quantification of tumor:normal tissue AUC ratios and steady-state concentration ratios.