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Proposed model for the action of ADAP1. KIF13B transports ADAP1 along microtubules in dendrites (i) until it reaches regions of high PIP3 or PI(3,4)P2 concentration. Here, ADAP1 is released from KIF13B (ii) and recruited to the membrane (iii), where it stimulates GTP hydrolysis and membrane detachment of ARF6 (iv).
