. Author manuscript; available in PMC: 2021 Jan 20.

Published in final edited form as: J Alzheimers Dis. 2020;76(2):539–551. doi: 10.3233/JAD-191192

Table 4.

Parameter estimates (and 95% confidence intervals) of sex limitation ACE models for All Dementia, AD only, and Non-AD Dementia

	All Dementia
Group	A	C	E	r_g	Thresholds	b_Age	b_Age²
Male	.41 (.03 – .79)	.15 (−.15 – .44)	.44 (.30 – .59)		1.69	1.09 (0.96 – 1.22)	−0.14 (−0.19 – 0.09)
Female	.59 (.34 – .83)	.13 (−.06 – .32)	.28 (.19 – .37)		1.73	1.59 (1.48 – 1.70)	−0.18 (−0.21 – −0.14)
DZOS				0.5
	Alzheimer’s Disease Alone
Group	A	C	E
Male	.65 (.36 – .94)	.10 (−.12 – .33)	.25 (.13 – .36)		1.89	0.87 (0.72 – 1.03)	−0.06 (−0.12 – 0.01)
Female	.54 (.24 – .85)	.24 (−.02 – .49)	.22 (.13 – .32)		1.89	1.03 (0.93 – 1.14)	−0.05 (−0.09 – −0.01)
DZOS				0.5
	Non-Alzheimer’s Disease Alone
Group	A	C	E
Male	.10 (−.44 – .64)	.28 (−.14 – .69)	.62 (.38 – .86)		2.13	1.43 (1.26 – 1.61)	−0.28 (−0.35 – −0.21)
Female	.53 (.09 – .96)	.11 (−.20 – .41)	.37 (.17 – .58)		2.41	2.43 (2.18 – 2.69)	−0.48 (−0.56 – −0.39)
DZOS				0.5

Note. Parameter estimates come from the full model (Model 2), with r_g set to 0.50. For All Dementia, AD Only, and Non-AD Dementia, A, C, and E can be set equal in men and women without significant loss of model fit. A = additive genetic variance component; C = shared environmental variance component; E = nonshared environmental variance component