Table 6.
Parameter estimates of mixed-effects ordinal regression analyses for All dementia and AD only occurrence and linear mixed-effects regression analyses for age at onset of All dementia and AD only
| a) Mixed Ordinal Regression Results for Disease Occurrence | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All Dementia | Alzheimer’s Disease Only | |||||||||||
| Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | |||||||
| Model Parameters | Estimate | SE | Estimate | SE | Estimate | SE | Estimate | SE | Estimate | SE | Estimate | SE |
| Fixed Effects | ||||||||||||
| Intercept | 0.24 | 0.12 | −0.21 | 0.12 | −0.18 | 0.13 | −0.84 | 0.18 | −1.38 | 0.19 | −1.33 | 0.21 |
| Sex | 0.27 | 0.13 | 0.28 | 0.13 | 0.24 | 0.15 | 0.72 | 0.19 | 0.71 | 0.18 | 0.63 | 0.22 |
| APOE4 | - | - | 1.21 | 0.14 | 1.14 | 0.20 | - | - | 1.64 | 0.21 | 1.51 | 0.29 |
| Sex*APOE4 | - | - | - | - | 0.13 | 0.25 | - | - | - | - | 0.23 | 0.34 |
| Random Effects | ||||||||||||
| σ2Intercept | 1.74 | 0.48 | 1.22 | 0.41 | 1.24 | 0.41 | 3.63 | 1.13 | 2.71 | 0.94 | 3.32 | 1.06 |
| Fit Statistics | ||||||||||||
| Deviance | 2281.40 (5) | 2182.16 (6) | 2181.91 (7) | 1690.03 (5) | 1589.83 (6) | 1589.35 (7) | ||||||
| AIC | −1145.70 | −1097.08 | −1097.96 | −850.01 | −800.91 | −801.68 | ||||||
| BIC | −1158.45 | −1112.38 | −1115.81 | −862.32 | −815.68 | −818.90 | ||||||
| b) Mixed Effects Regression Results for Age at Onset | ||||||||||||
| All Dementia | Alzheimer’s Disease Only | |||||||||||
| Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | |||||||
| Model Parameters | Estimate | SE | Estimate | SE | Estimate | SE | Estimate | SE | Estimate | SE | Estimate | SE |
| Fixed Effects | ||||||||||||
| Intercept | 79.30 | 0.38 | 80.11 | 0.42 | 79.83 | 0.48 | 79.23 | 0.54 | 80.09 | 0.59 | 80.08 | 0.68 |
| Sex | −0.12 | 0.46 | −0.14 | 0.45 | 0.29 | 0.57 | −0.81 | 0.61 | −0.85 | 0.61 | −0.84 | 0.79 |
| APOE4 | - | - | −1.65 | 0.35 | −1.10 | 0.57 | - | - | −1.58 | 0.45 | −1.57 | 0.78 |
| Sex*APOE4 | - | - | - | - | −0.87 | 0.72 | - | - | - | - | −0.02 | 0.95 |
| Random Effects | ||||||||||||
| σ2Intercept | 8.43 | - | 8.03 | - | 7.91 | - | 12.54 | - | 12.22 | - | 12.22 | - |
| σ2Residual | 32.99 | - | 32.41 | - | 32.46 | - | 28.35 | - | 27.77 | - | 27.77 | - |
| Fit Statistics | ||||||||||||
| Deviance (df) | 6010.90 (6) | 5989.20 (7) | 5987.70 (8) | 3542.90 (6) | 3530.90 (7) | 3530.90 (8) | ||||||
| Δχ2/Δdf | - | 21.70 (1) | 1.50 (1) | - | 12.00 (1) | 0.001 (1) | ||||||
| p-value | - | < .001 | .221 | - | < .001 | .981 | ||||||
| AIC | 6022.90 | 6003.20 | 6003.70 | 3554.90 | 3544.90 | 3546.90 | ||||||
| BIC | 6051.90 | 6036.90 | 6042.30 | 3580.70 | 3575.00 | 3581.30 | ||||||
Notes. In the models in Section a, odds ratios can be ascertained by exponentiating parameter estimates. AIC = Akaike Information Criterion; BIC = Bayesian Information Criterion.