Skip to main content
. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Immunol Rev. 2020 May 15;296(1):48–61. doi: 10.1111/imr.12860

Figure 3. Model of BTLA action as a cell-extrinsic suppressor of GC lymphomagenesis.

Figure 3.

(A) HVEM-expressing GC B cell recruits BTLA to immunological synapse. BTLA signals into Tfh cell through SHP-1, which reduces the strength of TCR signal and amount of preformed CD40L mobilized to the cell surface. (B) In the absence of HVEM, BTLA is not recruited to the immune synapse and the amount of preformed CD40L mobilized to the surface is increased. The HVEM-deficient B cell receives increased CD40 signaling.