Table 1.
Correlation of CFR and DDR with HLA-B allele frequencies across 60 countries.
| Allele | Number of SBa | Average allele frequency | CFR |
DDR |
||
|---|---|---|---|---|---|---|
| rs | p | rs | P | |||
| −21 M | – | 0.165 | 0.03 | 0.78 | 0.37 | 0.0032 |
| −21 T | – | 0.590 | −0.02 | 0.84 | −0.15 | 0.23 |
| HLA-B*07:02 | 61 | 0.053 | 0.02 | 0.85 | 0.35 | 0.0053 |
| HLA-B*08:01 | 82 | 0.045 | 0.10 | 0.40 | 0.5 | <0.0001 |
| HLA-B*13:01 | 125 | 0.017 | −0.02 | 0.90 | −0.45 | 0.0003 |
| HLA-B*13:02 | 122 | 0.015 | −0.17 | 0.19 | 0.04 | 0.76 |
| HLA-B*14:02 | 167 | 0.017 | 0.04 | 0.76 | 0.37 | 0.0031 |
| HLA-B*15:01 | 128 | 0.032 | −0.01 | 0.91 | 0.22 | 0.09 |
| HLA-B*15:02 | 195 | 0.019 | 0.17 | 0.19 | −0.25 | 0.06 |
| HLA-B*15:03 | 180 | 0.015 | 0.04 | 0.76 | 0.09 | 0.50 |
| HLA-B*18:01 | 101 | 0.037 | −0.22 | 0.08 | 0.14 | 0.27 |
| HLA-B*27:05 | 41 | 0.015 | 0.12 | 0.36 | 0.53 | <0.0001 |
| HLA-B*35:01 | 191 | 0.051 | 0.09 | 0.46 | 0.42 | <0.0001 |
| HLA-B*35:03 | 147 | 0.016 | −0.11 | 0.40 | 0.41 | 0.0011 |
| HLA-B*35:05 | 184 | 0.015 | 0.15 | 0.24 | −0.15 | 0.24 |
| HLA-B*38:01 | 134 | 0.012 | −0.06 | 0.64 | 0.51 | <0.0001 |
| HLA-B*39:01 | 157 | 0.015 | 0.04 | 0.78 | 0.04 | 0.76 |
| HLA-B*40:01 | 71 | 0.038 | 0.01 | 0.91 | −0.4 | 0.06 |
| HLA-B*40:02 | 70 | 0.03 | −0.04 | 0.75 | 0.03 | 0.83 |
| HLA-B*40:06 | 91 | 0.01 | −0.03 | 0.82 | −0.10 | 0.42 |
| HLA-B*42:01 | 80 | 0.011 | −0.03 | 0.80 | 0.008 | 0.95 |
| HLA-B*44:02 | 58 | 0.027 | 0.03 | 0.79 | 0.45 | 0.0003 |
| HLA-B*44:03 | 62 | 0.033 | 0.05 | 0.70 | 0.18 | 0.15 |
| HLA-B*45:01 | 95 | 0.013 | 0.06 | 0.64 | 0.08 | 0.53 |
| HLA-B*46:01 | 225 | 0.012 | −0.06 | 0.61 | −0.37 | 0.0034 |
| HLA-B*48:01 | 119 | 0.012 | 0.08 | 0.56 | −0.16 | 0.22 |
| HLA-B*49:01 | 77 | 0.013 | −0.05 | 0.69 | 0.20 | 0.12 |
| HLA-B*50:01 | 103 | 0.018 | −0.15 | 0.24 | 0.27 | 0.03 |
| HLA-B*51:01 | 111 | 0.059 | −0.08 | 0.50 | 0.38 | 0.0022 |
| HLA-B*52:01 | 147 | 0.022 | −0.04 | 0.74 | 0.13 | 0.30 |
| HLA-B*53:01 | 108 | 0.023 | −0.07 | 0.56 | 0.04 | 0.71 |
| HLA-B*56:01 | 113 | 0.015 | −0.08 | 0.50 | −0.38 | 0.0027 |
| HLA-B*57:01 | 71 | 0.016 | 0.09 | 0.48 | 0.48 | <0.0001 |
| HLA-B*58:01 | 87 | 0.028 | −0.07 | 0.57 | −0.34 | 0.0062 |
The correlations that remained significant after correction for multiple tests are highlighted in bold. CFR = case fatality rate; DDR = daily death rate; rs = Spearman’s correlation coefficient; ns = not significant. aThe number of strong binders is the number of peptides of the SARS-CoV-2 proteome that binds strongly each HLA-B allele. Significant p values after correction (pc): HLA-B*08:01, pc = 0.00016; HLA-B*13:01, pc = 0.0096; HLA-B*27:05, pc = 0.0000000032; HLA-B*35:01, pc = 0.0022; HLA-B*35:03, pc = 0.03; HLA-B*38:01, pc = 0.00022; HLA-B*44:02, pc = 0.0096; HLA-B*57:01, pc = 0.00013.