Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 20;113(2):564–575. doi: 10.1016/j.ygeno.2020.12.041

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Elsevier Inc.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Fig. 4 — Drug repositioning based on up-regulated DEGs from ΔORF6-infected cells. Chord diagrams (top) and tables (bottom) showing the relationship between ΔORF6-specific (“specific”) and wild-type-sharing (“shared”) to cluster categories (“cluster 1” or “other”) of (A) drug-gene pairs; (B) up-regulated DEGs; (C) intersected genes between up-regulated DEGs and targetable (druggable) genes; and (D) candidate ligands for repurposing. (E) Venn diagram showing the intersected number of candidate ligands between ligands from ΔORF6-specific (“Specific”) or wild-type-sharing (“Shared”) and cluster categories (“Cluster 1” or “Other”). (F) Bar plot showing the number of targeting DEGs (x-axis) of candidate ligands. The numbers of ligands that may target 1– 5 up-regulated DEGs are counted (y-axis).