Figure 2.

Phosphatidylserine exposure on the surface of cells exposed to plasma results in thrombin generation and complement system activation - Blood coagulation proteins have phosphatidylserine-binding domains, which allows them to cluster together on exposed PS, accelerating their interaction and the subsequent generation of thrombin. PS can lead to activation of the complement system. Together, the coagulation and complement systems contribute to the complex clinical phenotype of thromboinflammation.