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. 2020 Oct 20;147(2):361–371. doi: 10.1007/s00432-020-03428-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Cellular functions of breast cancer cell clones upon 6 days of conditional miRNA mediated ITGB3 knockdown a Cellular proliferation determined by MTT assay; b cellular migration; these assays were run with two controls: the parent cell clone and an additional control clone (Ic), which contains the gene cassette without miRNA sequence. The conditional ITGB3 knockdown provoked slight, but significant inhibition of proliferation in I5 cells only, whereas migration was decreased in both cell clones I3 and I5, yet more pronounced in I5 cells. ***p < 0.001 versus controls