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. 2020 Oct 20;147(2):361–371. doi: 10.1007/s00432-020-03428-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Gene modulation upon integrin beta-3 knockdown (ITGB3 KDN) Downregulation of selected genes after 3 and 6 days of ITGB3 miRNA-mediated inhibition. The gene expression of the cell clone with conditional ITGB3 knockdown was compared to that of the same cell clone cultivated in media with doxycycline (the corresponding control). The dashed line indicates a fold change without gene expression modulation, the asterisks indicate a significantly altered fold change (p < 0.001). The genes include NPTN (neuroplastin), ISCA1 (iron-sulfur cluster assembly 1), SEPT11 (septin 11), STX6 (Syntaxin 6), and RRM2 (ribonucleotide reductase M2 polypeptide). The right side of the figure shows the respective gene functions