Table 2.

Outcome upon palliative chemotherapy

Systemic therapy
Monotherapy	N = 105	54.4%
Platinum doublet	N = 51	26.4%
Other combination	N = 37	19.2%
Number therapy lines (median)	2 range (1–4)
2nd line received	91	47.2%
3rd line received	50	25.9%
4th line received	20	10.4%
CR	N = 2	1.0%
PR	N = 19	9.8%
SD	N = 39	20.2%
PD	N = 97	50.3%
n.e	N = 36	18.7%
Overall response rate (ORR)	N = 21	10.9%
Disease control rate (DCR)	N = 60	31.1%
Median PFS of 1st line CTX	2.9 months	(95% CI 2.2–3.6 months)
Median PFS of 2nd line CTX	3.2 months	(95% CI 2.0–4.3 months)
Median PFS of 3rd line CTX	2.1 months	(95% CI 1.7–2.4 months)
Median PFS of 4th line CTX	1.8 months	(95% CI 1.6–2.0 months)
Median OS entire population	11.2 months	(95% CI 9.3–13.2 months)
Median OS locally/locally advanced	26.4 months	(95% CI 20.3–30.6 months)
Median OS metastatic disease	9.4 months	(95% CI 7.5–11.2 months)

PFS progression-free survival, OS overall survival