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. 2020 Nov 16;147(2):435–443. doi: 10.1007/s00432-020-03429-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Discriminative ability of M371. ROC curves showing the high sensitivity and specificity of the M371 test for detecting TGCT (n = 20) by comparison to (a) the entire group of other patients (n = 136; AUC, 0.991), b patients with benign testicular tumours of non-germ cell origin (n = 69; AUC, 0.996), c patients with testicular lymphoma (n = 30; AUC, 0.972) and d control patients (n = 37; AUC, 0.996). The specificity of M371 for testicular germ cell tumours is 90% in all calculations. The sensitivity of M371 depends on the histologic subgroup for comparison (a–d)