Table 3.

Cox proportional hazard for overall survival (n = 103)

Variable	No.	Median OS [months]	Univariate		Multivariate
			Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Ratio pYAP/YAP expression
pYAP > YAP	53	19.0	1.00		1.00
YAP > pYAP	50	13.0	1.34 (0.86–2.11)	0.20	1.57 (0.53–4.71)	0.42
YAP expression
Negative	31	17.0	1.00		1.00
Positive, weak	22	24.0	0.66 (0.34–1.28)	0.22	0.34 (0.13–0.89)	0.78
Positive, mild	35	14.0	0.89 (0.51–1.56)	0.69	1.19 (0.16–1.54)	0.12
Positive, strong	15	13.0	1.01 (0.52–2.20)	0.84	1.03 (0.19–2.43)	0.49
pYAP expression
Negative	36	13.0	1.00		1.00
Positive, weak	13	9.0	1.79 (0.90–3.56)	0.09	1.27 (0.49–3.24)	0.62
Positive, mild	28	25.5	0.47 (0.26–0.84)	0.01	0.41 (0.17–0.99)	0.04
Positive, strong	23	21.0	0.69 (0.36–1.23)	0.19	1.42 (0.40–4.96)	0.59
Tumour pathological stage
T1	8	19.0	1.00		1.00
T2	12	10.0	1.66 (0.39–6.97)	0.49	0.94 (0.19–4.47)	0.94
T3	70	9.0	2.64 (0.83–8.46)	0.10	1.30 (0.37–4.62)	0.69
T4	13	13.0	2.74 (0.75–10.1)	0.13	2.14 (0.56–8.23)	0.27
Nodal status
N0	25	23.0	1.00		1.00
N1	70	16.0	1.74 (0.95–3.19)	0.08	1.90 (0.94–3.85)	0.13
N2	8	9.0	2.85 (0.91–8.98)	0.07	3.09 (0.84–11.4)	0.52
Metastasis status
M0	61	20.0	1.00		1.00
M1	42	11.5	1.66 (1.05–2.62)	0.03	2.19 (0.71–6.83)	0.17
Tumour differentiation
Well-differentiated	7	33.0	1.00		1.00
Moderately differentiated	24	20.0	2.19 (0.72–6.65)	0.17	2.06 (0.58–7.33)	0.26
Poorly differentiated	67	14.0	3.10 (1.10–8.65)	0.03	2.65 (0.84–8.39)	0.09
Anaplastic	5	16.0	1.96 (0.43–8.87)	0.38	1.51 (0.28–8.23	0.64
Resection margin
R0	68	17.0	1.00		1.00
R1	35	14.0	1.24 (0.77–2.01)	0.37	1.08 (0.61–1.92)	0.78

CI confidence interval