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. 2021 Jan 7;11:619951. doi: 10.3389/fimmu.2020.619951

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Copyright © 2021 Johnson, Drummer IV, Shan, Shao, Sun, Lu, Saaoud, Xu, Nanayakkara, Fang, Bagi, Jiang, Choi, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MicroRNA-155 transcripts are decreased in white adipose tissue (WAT) of obese wild-type (WT) mice compared with WAT of apolipoprotein E (ApoE)^-/- mice. (A) Mice were kept on either normal chow (NC) or switched to high-fat diet (HFD) at 8 weeks old and fed for an additional 12 weeks. ApoE^-/- NC (n=6); apoE^-/- HFD (n=7); WT HFD (n=4). *p < 0.05. (B) Obese patients with or without type 2 diabetes mellitus (T2DM). Donor information detailed in Table 3. Obese (n=2), Obese, T2DM (n=4). p > 0.05. NS, not significant.