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. 2021 Jan 7;11:619951. doi: 10.3389/fimmu.2020.619951

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Copyright © 2021 Johnson, Drummer IV, Shan, Shao, Sun, Lu, Saaoud, Xu, Nanayakkara, Fang, Bagi, Jiang, Choi, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Macrophages and monocytes are increased in miR155-deficient, high fat diet (HFD)-fed male mice in the presence or absence of ApoE background. Mice were fed on HFD from 8 weeks old to 20 weeks old. (A) Male mice: Total leukocytes were defined as CD45+. Macrophages/monocytes were defined as (B) CD45+F4/80+ or (C) CD45+CD11b+. (D) Inflammatory monocytes were defined as CD45+Ly6C+. (E) CD4+ T lymphocytes were defined as CD45+CD4+. (F) B lymphocytes were defined as CD45+CD19+. (G) B/T lymphocyte subsets were defined as CD45+CD5+; ApoE^-/- (n=7), DKO (n=11). (H) Female mice: Total leukocytes were defined as CD45+. (I) Macrophages were defined as CD45+F4/80+; ApoE^-/- (n=5), DKO (n=4). (J) Male mice: Total leukocytes were defined as CD45+. (K) Macrophages were defined as CD45+F4/80+; WT (n=8), miR155^-/- (n=9). **p<0.01. NS, not significant.