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. 2021 Jan 7;11:619951. doi: 10.3389/fimmu.2020.619951

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Copyright © 2021 Johnson, Drummer IV, Shan, Shao, Sun, Lu, Saaoud, Xu, Nanayakkara, Fang, Bagi, Jiang, Choi, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A novel subset of CD95⁺CD86^- macrophages is increased in the white adipose tissues of DKO versus that of ApoE^-/- mice on high-fat diet. Mice were fed on HFD from 8 weeks old to 20 weeks old. Macrophages were defined as CD45⁺F4/80⁺ and then evaluated for the markers, CD95 and CD86. (A, B) Male mice: ApoE^-/- (n=5), DKO (n=4). (C, D) Female mice: ApoE^-/- (n=5), DKO (n=4). *p<0.05. NS, not significant.