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. 2021 Jan 7;11:619951. doi: 10.3389/fimmu.2020.619951

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Copyright © 2021 Johnson, Drummer IV, Shan, Shao, Sun, Lu, Saaoud, Xu, Nanayakkara, Fang, Bagi, Jiang, Choi, Wang and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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There are no differences in the expressions of three pro-inflammatory markers such as IL-1b, TLR4 and Fas in DKO aortas compared with ApoE-/- aortas following HFD. The expressions of IL-1b and Fas are significantly increased in DKO aortas compared with miR155-/- single KO aortas. A-C. Male mice were fed on HFD for 12 weeks from 8 weeks old to 20 weeks old. (A) Il-beta. (B) Tlr4. (C) Fas; n=3 per group. *p<0.05.