Table 2. Results of the Univariable and Multivariable Cox-Proportional Hazard Model for Evaluating the Factors Associated with Overall Survival in the Training Cohort (n = 525).
| Variable | Univariable Cox Regression Analysis | Multivariable Cox Regression Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | Adjusted HR | 95% CI | P | |
| Irregular tumor margin | 2.347 | 1.806–3.049 | < 0.001 | 1.821 | 1.288–2.573 | 0.001 |
| Atypical tumor enhancement | 2.216 | 1.622–3.029 | < 0.001 | 1.459 | 0.964–2.208 | 0.074 |
| Central tumor location | 1.417 | 1.036–1.937 | 0.029 | 1.465 | 1.069–2.008 | 0.018 |
| Age (≥ 65 years, n = 126) | 2.311 | 1.774–3.012 | < 0.001 | 1.882 | 1.407–2.518 | < 0.001 |
| Male sex | 0.871 | 0.637–1.191 | 0.386 | NA | NA | NA |
| Etiology | ||||||
| HBV | 1.000 | < 0.001 | 1.000 | 0.091 | ||
| HCV | 2.007 | 1.406–2.866 | < 0.001 | 1.426 | 0.973–2.072 | 0.067 |
| Others | 1.817 | 1.252–2.639 | 0.002 | 1.376 | 0.943–2.058 | 0.109 |
| Tumor size (≤ 2 cm, n = 321) | 0.880 | 0.777–0.997 | 0.045 | 0.943 | 0.830–1.072 | 0.369 |
| Total bilirubin | 1.094 | 0.821–1.456 | 0.541 | NA | NA | NA |
| Albumin (≤ 3.7, n = 272) | 1.918 | 1.482–2.482 | < 0.001 | 1.682 | 1.292–2.190 | < 0.001 |
| AFP (≥ 14.3 ng/mL, n = 263) | 1.085 | 0.845–1.393 | 0.521 | NA | NA | NA |
CI = confidence interval, HR = hazard ratio, n = number, NA = non-applicable